No one is born with a gender. So to answer your question simply, no.
By "Should we be configured to the gender we are born with?" if you literally mean "is it normal for humans gender and sex to be correlated", absolutely, a very small portion of the population is gender variant, transsexuals are uncommon.
BUT I'm guessing you mean "should we remain the sex we are born as" and personally I think it's quite invasive and rude when people criticize transsexuals for "changing their bodies" when it's a mental health issue. It's not much better than telling a person with a horribly disfigured face that they're humiliated by that they shouldn't get plastic surgery because it's "changing what god gave you". Transsexuals VERY often kill themselves when they're young because of intense dysphoria, humiliation and depression, no one should EVER be able to tell them that they don't deserve to be happy because "it's weird/wrong to change their bodies". People should stay out of other people's business when it comes to sex/gender issues, it doesn't concern anyone but the person themselves. Sorry if I sound rude, but this is a very personal issue for not only myself, but people I've lost, and close friends who struggle every day.