It only really bothers me when it's blatant. Like if it's "This clitoral stimulator is sure to drive her wild!" I'm not too upset, but if it's like "This plug is only for the manly man; only manly men can use such a masculine toy, because only manly men have prostates!" or something like that (I was a bit exaggerated) I would be a little upset.
While I would LOVE to live in a society that acknowledged that, while there may be two main sexes, there are an infinite number of gender identities... Western culture just doesn't seem to be fond of that idea. It would make things less 'easy,' but it would for sure make people feel more included. (It also would have made puberty a lot less confusing for me hahaha)