I was diagnosed as bipolar back in my teens, and they tried all kinds of medications... Lithium, zoloft, effexor, welbutrin, risperadol (I'm sure I'm spelling these wrong).
None of them really worked all that well for me except effexor, but that was prescribed when I was about 20 and the doctor decided I had depression instead...
I finally got fed up with all the drugs frying my brain (I can't remember most of my teenage years, and I wasn't one of those kids who partied), so I stopped taking the meds. I am now more stable and happy than I ever was on the medications.
I'm not saying that everyone should stop taking their meds... Some people need them. They were just really messing me up, mentally. I now take St. John's Wort when I'm moody, and that's more than sufficient.