As far as I know, you can plug the OhMiBod toys into anything with a headphone jack. As most computers/computer speakers have headphone jacks, that would mean that it would be compatible with any of the noise you have going on on your computer - including Skype (or video games if you want to have fun with it!)
We've never tried Skype with our OhMiBod toys though. Hmm. Something new to try.