Yes, there are differences! The internal texture is the major difference with most of them. The external features, like the case, style of the orifice (usually a pussy, ass, or mouth), and the color are mostly cosmetic. One exception is the new Crystal series which has a clear case and a translucent sleeve that you can see through - which can be really hot for some people. There are also different types of Fleshlight styles - light their "Sex-in-a-Can" series which are usually a bit tighter and for small to average sized men.