Absolutely. I've been on both sides of the table.
Right out of college, I applied for a job, based on a description which clearly said "entry level, no experience required", but during the interview, when I told the manager I didn't have any experience, he actually started shouting at me, like "Why are you wasting my time!" Believe it or not, the company ended up offering me the job (I turned them down!).
I've always found it awkward to be asked how much salary I'm looking for (the "correct" answer to this, btw, is that, at this time, you're just interested in learning more about the position; you'll be "open to a competitive offer", should you decide the job's right for you). I've also been asked my age before, which is against the law in the US, as well as my political beliefs once (also a no-no).
My awkward moments as the guy doing the hiring are too numerous to go into here! Suffice it to say, I've seen some real jokers over the years.