If you held the bumped "juicer" end in your hand and inserted the smooth wavy end it would work. I don't think I'd recommend using it any other way - the nubs will likely be too much, and it would be hard to hold on to.
This can be used anally on either end, I'm almost positive that someone has used it for that purpouse. Even if a partner were to hold the small end so that it wouldn't slip in ending the night with a hospital visit.
It's larger and more textured than I can handle, especially because it's glass. BUT, even if it wasn't, I wouldn't try it, because it would be hard to keep a good grip on the small end, especially with lube and such.