Silicone lube is a pretty good solution, but I've found that things like powders actually do work quite well in the short term. the problem is that - especially when running - one tends to sweat, which pretty much renders the powder useless. I don't know anything about lotions or creams, though the statement that they only soothe instead of protect seems likely to me - I mean, they're made to dissolve into the skin. Deodorant does protect freshly-shaven underarms from chafing, though, so there might be some lotiony-type things that act the same way? Probably not just your everyday hand lotion, though. Baby powder would work well, though, or any other fine body-safe powder that you don't mind chucking in your purse to reapply.

Bandelettes are pretty cool too - they're like stay-up thigh highs without the nylons. I don't own a pair, but I have heard that they work pretty well. Plus they're way sexier than Spanx (which I do own a pair of and adore... as long as no one else can see them).