Ladies. Without offending you...

If the comment isn't meant to be creepy, it likely won't be unless you have few social skills. What matters most to me is the context, where we are, what I am doing, and how someone acts while complimenting me. If we are in a club or bar, I don't mind nearly as much (unless I'm sitting at a table with a partner, and then that is rude) but if I am at work or I'm walking on the street and look like I'm in a hurry, not just enjoying a stroll, don't bother. If someone gets uncomfortably close, it doesn't matter what they are saying, that's creepy. If they are talking to my chest, creepy. If they are giving me an up-down look, creepy. If they look me in the eyes and tell me something that's just a nice compliment, I'll respond much better.