It depends on how sensitive you happen to be & where the product is to be placed. You need to be careful of anything used on your genitals, especially mucous membranes! For general skin use such as massage lotions with, for example, a warming effect, it's usually safe & well tolerated by most. The problem with most products is that they are using known irritants which may not bother you until after repeated exposure. Educate yourself online or by asking a healthcare professional if you're concerned.

Unfortunately, I'm allergic to or have a bad reaction to so many chemicals. I read the ingredients of everything, but you should know that manufacturers don't have to list ingredients below a certain percentage of the formula. They also have ways of 'hiding' ingredients by using less familiar names or listing under catch all terms such as fragrance or spices.

The lubes I've tried have either made me itch like crazy either immediately or after the inevitable yeast infection kicked in, or they have burned like hellfire! I may have found some winners in the Sliquid line, but am still testing those.

I did try a G-spot cream with L-Arginine, but without the common irritants menthol & peppermint, (don't use if you have herpes). It actually did warm the area, but not for long & didn't affect my orgasm. I need to experiment, but doubt I'd try it again.

As for relaxing creams, I'm assuming you mean for the anus? I believe there are even some products meant to relax, (read numb), your throat for deep throat. Anything that dulls your receptors is dangerous when engaged in an activity that could cause harm. Pain is your body telling you something is wrong! Products that interfere with that feedback are dangerous & I believe unnecessary.

I don't know the long term safety of prolong creams for men, but can say I wouldn't want any of that product to come in contact with my genitals. In general they seem to be well tolerated by some men, but there are other options such cock rings & tricks with condoms.

Your best bet is to apply a small amount of whatever product you bought to an area on the inside of your elbow & wait 24 hours to see if you get a reaction. If not, then try testing the same way on the outside of your vulva or in the crease of your groin. This may seem like overkill, but as someone who's sustained burns on my labia & vagina, I'll tell you it's easier to first do a patch test!

PS, Let me just add that substances applied to your skin can be absorbed into your body, so be careful what products you use. Interestingly, in studies performed on cadavers, they discovered foundation makeup & body lotion in lymph nodes!